ANALGIN-HININ (Metamizole sodium 200 mg + Quinine 50 mg) – metamizole sodium is a pyrazolone derivative and has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with inhibition of prostaglandin synthesis by inhibiting COX. Quinine inhibits the center of thermoregulation, in high doses – the auditory and visual zones of the cerebral hemispheres. Also, quinine inhibits the development of erythrocytic forms of schizonts and malaria gamonts, suppressing DNA replication, and has a local irritating and local anesthetic effect. The pharmacological action develops within 20-40 minutes after taking the drug and reaches a maximum after 2 hours.
Renal and biliary colic (in combination with antispasmodics).
Metamizole sodium can cause agranulocytosis and thrombocytopenia. The development of agranulocytosis does not depend on the dose and cannot be foreseen and may occur after the first use or after repeated use. Typical signs of agranulocytosis are fever, sore throat, painful swallowing, inflammation of the mucous membranes of the mouth, nose, pharynx, anorectal and genital areas. With a sudden deterioration of the general condition and the appearance of signs of agranulocytosis, treatment with metamizole sodium should be discontinued and the blood samples should be examined.
Metamizole sodium can provoke hypotensive reactions. These reactions are dose-dependent and are observed mainly with parenteral administration.
Despite this, treatment with metamizole sodium in the form of tablets should be carried out with extreme caution in patients with hypotension, volumetric fluid deficiency in the body or dehydration, unstable blood circulation. Do not use the drug for acute abdominal pain (until the cause is clarified).
In the event of side effects (including those not mentioned above), the patient should stop taking the drug and consult a doctor.
In patients suffering from bronchial asthma and pollinosis, hypersensitivity reactions may develop.
Influence on the ability to drive vehicles and mechanisms:
During the period of taking the drug, you should not drive vehicles and work with mechanisms, because there is a risk of decreased ability to concentrate and speed of psychomotor reactions.
PACKAGE & DOSAGE
The medication comes 250 mg tablets. The pack contains 20 tablets.
Active substance: metamizole sodium (as 100%) 200 mg, quinine hydrochloride 50 mg.
Excipients: microcrystalline cellulose (Avicel PH 101) (75.00 mg), sodium carboxymethyl starch (primogel) (26.00 mg), colidone-25 (povidone) (3.00 mg), talc (5.00 mg), magnesium stearate (1.00 mg).
Treatment duration as an antipyretic agent is no more than 3 days, as an analgesic agent – no more than 5 days.
The tablets should be taken without chewing after meals.
For adults and children over 14 years of age, the drug is prescribed for 1-2 tablets. 1-3 times a day, depending on the clinical picture.
Children aged 12-14 years old – 1 tab. 3 times a day.
Store the medication at normal room temperature in a dry place. It is necessary to preserve the drug in its original packing, away from heat. If the capsules stick to each other due to heat or were destroyed, the product should not be taken. Throw away cracked or leaking medication.